David Zwirner is located at 525 West 19th Street in Chelsea (212-727-2070, davidzwirner.com). They have a second gallery at 537 West 20th Street between 10th and 11th Avenue.
GAGOSIAN GALLERY: Gagosian's a major name in the global gallery scene, with locations in Los Angeles (where the first Gagosian gallery opened in 1979), London, Paris, Rome, Hong Kong, Athens and Geneva, in addition to the several famed spaces in New York. All of the city's galleries have featured works by the biggest names in modern and contemporary art—Julian Schnabel, Damien Hirst, Andy Warhol, Richard Serra, Cy Twombly, Francis Bacon, etc.—with old masters occasionally on display as well. Exhibitions currently on display include a show focusing on Pablo Picasso's photography at the West 21st Street gallery and an exhibition of Takashi Murakami's painting and sculpture on West 24th Street.
There are a number of Gagosian Gallery locations in Manhattan. Visit their website for more information.
LUHRING AUGUSTINE: Luhring Augustine, founded in Chelsea in 1985, is one of the city's most reputable galleries, exhibiting and representing works by the likes of Gerhard Richter, Larry Clark, Pablo Picasso and David Musgrave. And Luhring Augustine was also one of the first major art galleries to expand beyond Manhattan's enclave, making headlines when it opened a Bushwick outpost off the Morgan Ave L stop in 2012. That location boasts a stellar exhibition space for installations.
Luhring Augustine has two locations in the city: 531 West 24th Street between 10th and 11th Avenues in Chelsea (212-206,9100, luhringaugustine.com) and at 25 Knickerbocker Avenue between Johnson Avenue and Ingraham Street in Bushwick, Brooklyn (718-386-276,luhringaugustine.com.com).
PIEROGI: This Williamsburg gallery may most recently be known for providing greater North Brooklyn with a lifetime supply of rock salt and human hamster wheels. But the 20-year-old space is one of Williamsburg's pioneering art hubs, boasting both exhibitions and the famed flat files showcasing hundreds of works by local artists that are up for sale (you can also view them online). Pierogi's also opened a second space, The Boiler, on North 14th Street, where they host larger installations and sculpture shows.
Pierogi is located at 177 North 9th Street between Bedford and Driggs Avenues in Williamsburg, Brooklyn (718-599-2144, pierogi2000.com). They've also got a secondary space at 191 North 14th Street between Nassau and Wythe Avenues in Williamsburg, Brooklyn.
FISHER LANDAU CENTER FOR ART: This LIC gallery, housed in an erstwhile parachute harness factory, of all places, contains hundreds of works belonging to 94-year-old collector Emily Fisher Landau. Landau's got quite an eye for art, having amassed works by the likes of Robert Rauschenberg, Ellsworth Kelly and Andy Warhol over the past half-century. You can peruse the permanent works in addition to intermittent temporary exhibitions highlighting specific pieces from Landau's collection.
The Fisher Landau Center for Art is located at 38-27 30th Street in Long Island City, Queens (718-937-0727, flcart.org).
SEAN KELLY GALLERY: Once a SoHo stalwart, Sean Kelly's 23-year-old gallery represents some of contemporary art's biggest names, including Robert Mapplethorpe, Marina Abramović and Mariko Mori. The gallery relocated to a two-story spot in Midtown a few years ago, and continues to host unconventional exhibitions, with upcoming shows including work by Chinese artist Sun Xun.
Sean Kelly Gallery is located at 475 Tenth Avenue between 36th and 37th Streets in Midtown West (212-239-1181, skny.com).
JACK SHAINMAN GALLERY: This DC transplant focuses on international work, with represented artists including the Ghanian El Anatsui, Malian artist Malick Sidibé and the Israeli Adi Nes. Not that the gallery shuns Americans: native Missourian Nick Cave is also represented by Jack Shainman, and the gallery just wrapped up a spectacular exhibition of his new work last month. Up next, the gallery will host work by Michigan native Titus Kaphar.
Jack Shainman has two locations in Manhattan: 513 West 20th Street between West Street and 10th Avenue in Chelsea (212-645-1701, jackshainman.com) and at 524 West 24th Street between 10th and 11th Avenues, also in Chelsea (212-337-3372, jackshainman.com).
CHEIM & READ: This spacious 6,000 square foot gallery helmed by John Cheim and Howard Read boasts a heavy-hitting list of represented artists, with names like Diane Arbus, William Eggleston, Louise Bourgeois and Joan Mitchell on their list. Upcoming exhibitions include shows by Danish artist Tal R and Ireland's Sean Scully; you can see Louse Bourgeois's fascinatingSuspension exhibition through mid-January.
Cheim & Read is located at 547 West 25th Street between 10th and 11th Avenues in Chelsea (212-242-7727, cheimread.com).
ON STELLAR RAYS: Candice Madey's LES gallery was one of the first to hit the Bowery back in 2008, opening just one day before Lehman Brothers brought the United States economy tumbling down. But On Stellar Rays, named after a 9th century text by Arab philosopher Al-Kindi, is a survivor, and continues hawking and displaying unique works by new and emerging artists. Current represented artists include Zipora Fried, Alix Pearlstein and JJ PEET; the gallery is about to close a breathtaking exhibition of Queens-based artist Tommy Hartung's work.
On Stellar Rays is located at 1 Rivington Street, between Chrystie and Bowery on the Lower East Side (212-598-3012, onstellarrays.com).
STOREFRONT FOR ART & ARCHITECTURE: Last but not least on this list is the Storefront for Art & Architecture, a 32-year-old triangular slice located in that SoHo/Little Italy no-man's land. Storefront's an all-around art "institution," a non-profit dedicated to supporting emerging and local art. But the gallery's one of the city's most treasured exhibition spots, displaying works by hundreds of artists, including Peter Cook, Yves Klein and David Molander. Right now, visitors can experience Jana Winderen and Marc Fornes's interactive installation Situation NY, on display through December 20th.
Storefront for Art & Architecture is located at 97 Kenmare Street in Nolita (212-431-5794,storefrontnews.org).
HONORABLE MENTIONS: There are so many important galleries in this city that we can't afford all of them individual blurbs. A few we missed include Maccarone, Gallery Lelong, Paula Cooper, Matthew Marks, PPOW, Metro Pictures, Lisa Cooley, Miguel Abreu, The Invisible Dog, Real Fine Arts and the 56 Bogart galleries. Note that many galleries, especially those in Chelsea, host openings on Thursday nights which often feature complimentary wine.